The TruDNA PLUS Difference

TruDNA PLUS is our most advanced formula for thwarting Father Time by naturally promoting longevity.  We’ve taken the formula of our original TruDNA nutrition to the next level of potency for even greater and faster results!  TruDNA PLUS is loaded with 26 scientifically validated “super nutrients” that encourages youthful cellular energy and vitality, promotes metabolic activity consistent with longevity, supports healthy cellular metabolism, modulates the expression of genes associated with some aspects of the aging process and much more.  You’ll obtain complete peace of mind that you’re receiving all the essential nutrients your body and mind need to live the healthiest, longest and happiest life.

Live Longer, Healthier and Happier With TruDNA PLUS

What sets TruDNA PLUS apart? Our powerful PLUS formula contains 26 of Mother Nature’s most powerful ingredients that are validated and supported by scientific research proving effectiveness and safety. TruDNA PLUS contains twice the amount of clinically studied herbs, vitamins, amino acids, minerals and adaptogens than all other nutritions on the market. We’ve increased the percentages of “super nutrients” from our original TruDNA formula, and added even more potent natural substances that promote longevity, including PQQ and Coenzyme Q10.


A compound found in blueberries, pterostilbene activates anti-aging molecular pathways and helps prevent the buildup of cellular waste products.  Studies show it modulates the hallmarks of aging, including oxidative damage, inflammation, telomere attrition and cell senescence. It has also been shown to provide DNA protection. You’ll experience more graceful aging, improved brain & heart health, healthier blood sugar, and better memory and cognition.

Astragaloside IV

In Traditional Chinese Medicine, the herb, Astragalus, is used for longevity, to invigorate vital energy (qi), and to strengthen bodily resistance to disease. Astragaloside IV - a saponin of this powerful herb - has shown benefits in reversing cell damage and activating telomerase, which addresses telomere shortening and slows down cellular aging. Telomeres are the protective ends of chromosomes that slowly shorten and wear out each time cell division occurs in the body, a process central to human aging. 

Japanese Knotweed

Native to Japan and China, Japanese knotweed is an excellent source of resveratrol that’s much more bioavailable than resveratrol found in red wine. Japanese knotweed contains high concentrations of trans-resveratrol, the active form of the compound that is best absorbed and utilized by the body. Research shows trans-resveratrol has anti-aging and anti-inflammatory properties, and helps to maintain healthy cardiovascular function, protect against cell damage and neurodegenerative diseases.


In humans, PQQ is typically found in miniscule concentrations. PQQ activates a number of vital cell signaling pathways involved in protecting against cellular aging. These synergistic effects have been shown to provide significant subcellular anti-aging benefits and enhance longevity. It also protects cells from oxidative damage that are associated with aging. PQQ promotes cognitive health and memory by combatting mitochondrial dysfunction, and protecting neurons from oxidative damage.

Coenzyme Q10

Test-tube and animal studies show that CoQ10 acts as a protective antioxidant in mitochondrial membranes and may prevent cognitive decline. It also improves arterial elasticity, and offers protection from hardening of the arteries that leads to heart disease.

Ashwagandha Root Extract

An ancient medicinal herb, it’s classified as an adaptogen so it protects the body from the effects of stress. Ashwagandha root has been shown to promote optimal levels of cortisol. It promotes healthy function of the immune, cardiovascular and nervous systems, as well as the brain, muscles and joints. Studies suggest that Ashwagandha root extract has many anti-aging effects. It significantly increases telomerase activity, which protects against telomere loss and potentially delays aging.

Serving Size:

3 capsules

Servings Per Container:


Amount Per Serving: % DAILY VALUE
Niacin (as niacinamide) 125 mg 781
Thiamine (as thiamine HCl) 20 mg 1667
Pantothenic Acid (as calcium pantothenate) 5 mg 100
Riboflavin (as riboflavin 5'-phosphate) 1.3 mg 100
Vitamin B6 (as pyridoxal 5'-phosphate) 1.7 mg 100
Folate (as calcium folinate) 200 mcg DFE 50
Vitamin B12 (as methylcobalamin ) 200 mcg 8333
Biotin 50 mcg 167
Magnesium (as Magnesium Bisglycinate Chelate) (TRAACS™) 50 mg 12
ATP and AMPK Cell Energy Blend
Pterostilbene 10 mg -
Rosmarinus officinalis Leaf Extract 200 mg -
Cinnamon Bark Extract (Cinnamomum burmannii) 200 mg -
Japanese Knotweed Extract (Polygonum cuspidatum)(root)(std. to 99% micronized resveratrol) 100 mg -
MitoDNA Repair Blend
Coenzyme Q10 (ubiquinone) 100 mg -
Alpha-Lipoic Acid 100 mg -
N-Acetyl-L-cysteine 100 mg -
PQQ (Pyrroloquinoline quinone) disodium salt 5 mg -
Adaptogenic Longevity Blend
Ashwagandha Root Extract (Withania somnifera)(std. to 1.5% withanolides) 300 mg -
Terminalia chebula Fruit Extract 50 mg -
Astragaloside IV (from Astragalus membranaceus root extract) 10 mg -
Black Pepper Extract (95% piperdine, Piper nigrum)(fruit) 10 mg -
AntiOx Healthy Aging
Citrus Bioflavonoid Complex (Citrus aurantium)(std. to 50% bioflavonoids) 50 mg -
Quercetin 50 mg -
Sophorae japonica L. Flower Extract (95% rutin) 50 mg -
Green Tea Extract (leaf)(std to 98% polyphenols, 50% ECGC) 45 mg -
Apigenin (Citrus grandis Fruit Extract ) 30 mg -

*Daily Value (DV) not established.
Additional Ingredients: Hypromellose (vegetable capsule)
TRAACS™ is a trademark of Albion Laboratories, Inc


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Superior Quality You Can Trust

Take the “Squeeze” Test

Check for yourself if your current nutrition measures up to TruDNA. Simply give it a squeeze and see if the capsule fills up. Did the company put in the maximum amount or leave empty space? Most companies “cheat” consumers by not completely filling their capsules to cut costs. And in their proprietary formulas, you won’t know the exact percentages of each ingredient you’re receiving. In fact, companies get away with providing the largest amount of the cheapest ingredient, since nobody is testing them, and less of the vital ingredients your body really needs. While other companies often use inferior ingredients to cut corners, we only include the most studied and researched nutrients with proven track records of providing extraordinary longevity benefits.

Trusted Partners

Our passion is to not only create the most effective adrenal support nutrition on the planet, but also support the environment and all living creatures. It’s more than just finding the most beneficial nutrients – it’s choosing to work with evolved companies and suppliers who care as deeply about the planet as we do. We take enormous pride in responsibly sourcing the highest quality plants, herbs, minerals, vitamins and adaptogens from our trusted partners.

Synergistic Science-Backed Formula

With science behind us and the most advanced nutritional research at our fingertips, our team of researchers blended 26 of the most potent and proven anti-aging nutrients that work synergistically to help slow Father Time. Our innovative formula supports healthy cell and protein function, DNA repair, youthful gene expression, optimal anti-inflammatory response, and much more.

Backed by Our “Empty Bottle” Guarantee

At TruSigma, your ultimate health and satisfaction is our #1 priority. If you’ don’t completely love TruDNA PLUS, let us know and we’ll cheerfully refund your full purchase price, no questions asked!

Exceptional Quality Control

Our stringent quality control is unsurpassed in the industry, and every step of production is held up to the highest standards. We work tirelessly to ensure each TruDNA PLUS bottle is manufactured to our exacting specifications, and then tested to ensure optimal purity and potency. Through this commitment, you’ll obtain peace of mind about the extraordinary care we put into TruDNA PLUS and all our exceptional health-supportive products.


Help the Body Adapt to Stress

Promotes Healthy Aging

Repairs DNA

Fights Fatigue on a Cellular Level

Youthful Gene Expression

Supports Healthy Protein Function